Curriculum Vitae -
Edward Cotlier, M.D.
ACADEMIC APPOINTMENTS:
1990- Present
Professor of Ophthalmology (Visiting) and Director of Genetic Course, University of Puerto Rico, San Juan, PR
Research Scientist, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY
Eye Birth Defects Foundation, Board Member, Scientific Board, Los Angeles, CA
Medical Consultant, United Nations
1990 – 1994
Clinical Director of Ophthalmic Services, Queens Long Island Medical Group, Ronkonkoma, NY
1986 – 1990
Chief of Ophthalmology, King Khaled University Hospital; Professor of Ophthalmology, King Saud University, Riyadh, SA.
1983 – 1985
Professor of Ophthalmology and Director of Cataract and Eye Genetic Laboratories, Cornell University, College of Medicine, Eye Consultant, Rockefeller University Hospital, New York, NY
1977 – 1983
Professor of Ophthalmology and Visual Sciences, Yale University School of Medicine, New Haven CT, Chief, Section of Genetic and Metabolic Diseases and Consultant, Veterans Administration Hospital, West Haven, CT
1976-1977
Chief of Ophthalmology, Buffalo General Hospital and Veterans Administration Hospital, Buffalo, NY
1970- 1976
Associate Professor (1970 – 1972) and Professor of Ophthalmology (1972 – 1976), University of Illinois Eye and Ear Infirmary, University of Illinois, Chicago, IL
1968 – 1970
Commander, US Navy, US Naval Hospital, Great Lakes, IL
1965 – 1968
Assistant Professor of Ophthalmology and Research Fellow, Department of Pharmacology (with O.H. Lowery), Washington University, School of Medicine, St. Louis, MO
1962 – 1966
Resident in Ophthalmology, Barnes Hospital, Department of Ophthalmology, Washington University, St. Louis, and Special Fellow, National Institute of Neurological Diseases and Blindness.
1960 – 1962
Fellow, National Council to Combat Blindness, Eye Biochemistry and Cataract Research, Department of Ophthalmology, Washington University School of Medicine, St. Louis, Missouri.
Specialty Board and Medical Societies:
Diplomate, American Board of Ophthalmology
Fellow, American Academy of Ophthalmology
Member, Association for Research in Vision and Ophthalmology
Member, New York Ophthalmological Society
Academic Honors and Awards:
United Nations (WAFUNIF) Awards, New York, NY
Yale University, MSc. (honorary)
American Academy of Ophthalmology, Honor Award
American Medical Association, Knapp Award
National Institute of Health, Career Development Award
XXI International Congress of Ophthalmology, Scientific Award
Waardenburg Medal, Nijmegen, The Netherlands
Education:
1954 B.S. College Nacional, Argentina
1959 M.D. Universidad del Litoral School of Medicine, Argentina
1977 MSc. Yale University, Master of Science (Honorary)
Programs Organized or Chaired:
National Eye Institute Cataract Workshop, National Eye Institute, Bethesda, May, 1976.
National Eye Institute Planning Subcommittee on Intraocular Lenses, 1976.
Jerusalem Conferences on Impaired Vision in Childhood, Section on Metabolic and Genetic Disease, 1977.
Symposium, “The Eye and Inborn Errors of Metabolism,” American Academy of Ophthalmology and Otolaryngology, 1977.
Cambridge University (England) Symposium, “The Lens and Cataracts,”1982.
VII European Congress of Ophthalmology, Symposium, “Genetics in Ophthalmology,” 1984.
National Foundation- March of Dimes: Symposium on “The Eye and Inborn Errors of Metabolism,” Oxford University, England, 1975.
Tokyo Symposium on “Genetic Diseases and the Eye,” International Society for Genetic Eye Diseases, 1978.
Israel Academy of Sciences, Symposium, “Genetics in Ophthalmology,” Jerusalem, Israel, 1981.
Ghent Symposium, “Genetic Eye Diseases,” International Society for Genetic Eye Diseases, 1984.
Amsterdam Symposium, “Genetic Diseases of the Eye,” International Society for Genetic Eye Disease, 1986.
Lisbon Symposium, “Genetic Diseases of the Eye and Retinoblastoma,” 1988.
London Symposium, “Congenital Cataracts,” Institute of Child Health, London, 1992.
United Nations Symposium, “Visual Disabilities in Children,” New York, 1992.
International Congress of Ophthalmology, Amsterdam, 1998.
Cedars-Sinai Medical Center, Los Angeles, CA “Genetic in Ophthalmology,” 1998, 2000, 2002, 2004.
Cedars-Sinai Medical Center, Los Angeles, CA “Retinal Stem Cells,” 2007.
Research Grants NIH/U.S. Government Advisory Board/Grant Reviewer:
NIH- National Eye Institute, Board Scientific
Counselors (1974–78), Visual Study Section (Division of Research Grants) (1978–82)
U.S. Veterans Administration (division of Research Grants) and FDA Ad-Hoc Reviewer (1982–02)
American Academy of Ophthalmology
Representative, National Society for Medical Research, Program Committee (1975–82)
American Medical Association, Ophthalmology Section
Member of Council and Representative for Scientific Exhibits (1972–77)
American Board of Ophthalmology Examiner (1972–94)
Foundation Fighting Blindness, Inc. (Retinitis Pigmentosa Foundation) Member, Advisory Board (1974–86)
Research to Prevent Blindness, Inc. Ad-hoc Reviewer
Research Grants Principal Investigator:
“Biochemical Studies in Normal and Cataractous Lenses,” National Institutes of Health, 1971–1984.
“Insulin and Growth Hormone Receptors in Retinal Blood Vessels,” National Institute of Health, 1978–1985.
Classification of Genetic Eye Disease in Saudi Arabia,” King Khaled Eye Specialist Hospital, Riyadh, 1986–1989.
“Diabetes: Evaluation of Complications,” King Saud University, Saudi Arabia, 1988–1989.
“Congenital Cataract Symposium,” National Foundation March of Dimes, 1992.
“Evaluation of Diabetic and Senile Cataracts” (Co-Investigator with Dominic V. Cicchetti, Ph.D.), Veterans Administration, Washington, D.C., 1993.
“Image Analysis in Medical Applications,” 1996–1999. Garcia Castaneira S and Cotlier E: NIH Core Grant to the University of Puerto Rico, PR.
Published Scientific Manuscripts: (Representative articles only)
MEDICAL/GENETICS
1. Goldberg, M.F., Cotlier, E., and Fichenscher, L.G., Kenyon, K., Enat, R., and Borowsky, S.A., Macular cherry-red spot, corneal clouding and B-galactosidase deficiency. Clinical, Biochemical, and electron microscopic study of new autosomal recessive storage disease. Arch. Intern Med., 128:387-398, 1971.
2. Singer, J., Cotlier, E., and Krimmer, R Hexosaminidase A in tears and saliva for identification of Tay-Sachs disease and its carriers. Lancet, 2:116-119, 1973.
3. Hindman, J. and Cotlier, E. Glycosidases in human normal leukocytes and abnormalitirs in GM1-gangliosidosis. Clin. Chem. 18:971, 1972.
4. Weiss, M., Krill, A., Dawson, G., Hindman, J., and Cotlier, E GM1-gangliosidosis: Type 1. Am. J. Ophthalmology, 76:99, 1972.
5. Del Monte, M., Johnson, D.L., Cotlier, E., Desnick, R.J., and Krivit, W. Diagnosis of Fabry’s disease by tear-galactosidase A.N. Eng. J. Med., 290:57-58, 1974.
6. Cotlier, E. Corneal cloudiness and retinitis pigmentosa in the mucopolysaccharidoses. N. Eng. J. Med., 292:812, 1975.
7. Johnson, L., Del Monte, M., Cotlier, E., and Desnick, R.J. Fabry disease: Diagnosis by alpha galactosidase activities in tears. Clin Chem. Acta 63:81-90, 1975.
8. Cotlier, E., and Reinglass, H. Marfan-like syndrome with lens involvement: hyaloideoretinal degeneration with anterior chamber angle, facial, dental, and skeletal anomalies. Arch. Ophthalmol. 93:93-106, 1975.
9. Cotlier, E., Reinglass, H., and Rosenthal, I. the eye in partial trisomy 2qsyndrome, Am. J. Ophthal., 84:251-258, 1977.
10. Cotlier, E. Café’-au-lait spots of the fundus in neurofibromatosis. Arch. Ophthal., 95:1990-200, 1977.
11. Cotlier, E., Rose, M. and Moel, S.A. Aniridia, cataracts and Wilms tumor in monozygous twins. Am. J. Ophtha. 86:129-132, 1978.
12. Reily, C., Cotlier, E., Jensen, P.S. and Klatskin, G. Arteriohepatic dysplasia: a benign syndrome of intrahepatic cholestasis associated with multiple organ involvement. Ann. Int. Med. 91:520-517, 1979.
13. Rosenfield, N.S., Kelley, M.J., Jensen, P.S., Cotlier, E., Rosenfield, A.T., and Riely, C.A. Arteriohepatic dysplasia: Radiologic features of a new syndrome. Amer. J. Roetgen. 135:1217-1223, 1980.
14. Puklin, J.E., Riely, C., Simon, R.S., and Cotlier, E. Anterior segment and retinal pigmentary abnormalities in arteriohepatic dysplasia. Ophthalmology 88:337-347, 1981.
15. Alghadyan, A., Kazi, R., Cotlier, E. Anophthalmos and First Branchial Arch. Defects. Opth. Paed. & Genetics. 6:169-178, 1985.
16. Resnick, K., Zucherman, J., and Cotlier, E. Cohen syndrome with bulls-eye macular lesion. Opth. Paed. & Genetics, 7:1-8, 1986.
17. Senft, S., Al-Kaff, A., Berqvist. G., Cotlier, E. Retinoblastoma: The Saudi Arabian Experience, Ophth. Pediatrics and Genetics. 8:125, 1988.
MOLECULAR BIOCHEMISTRY: Lens, Cataract, Retina
1. Cotlier, E., Obara, Y., and Toftness, B. Cholesterol and phospholipids in protein fractions of human lens and senile cataract. Biochem. Biophhys. Acta, 530:267-278, 1978.
2. Sternberg, P., Cotlier, E. and Obara, Y. Lyso-phosphatidyl ethanolamine on rabbit lens and levels in human lenses and senile cataracts. Exp. Eye Res. 26:729-737, 1978.
3. Rao, G.N. and Cotlier, E. Ornithine delta-aminotransferase activity in retina and other tissues. Neurochem. Res., Vol. 9, No. 4, 1984.
4. Rao, G.N., Cotlier, E. Urea cycle enzymes in retina, ciliary body iris, lens and senile cataracts. Exp. Eye Res. 39:483, 1984.
RETINA, LENS (Cataract)
PHARMACOLOGY/CLINICAL TRIALS
1. James, C.R.H. and Cotlier, E. The fate of insulin and growth hormone in the retina of the perfused bovine eye: An autoradiographic study. Brit. J. Oph., Vol. 67, 2:80-88, 1983.
2. Sharma, Y.R. and Cotlier, E. Inhibition of lens and cataract aldose reductase by protein-bound antirheumatic drugs: salicylate, indomethacin, oxyphenbutazone, sulindac. Exp. Eye Res. 35:21-27, 1982.
3. Vanisi, S.J., Edelhauser, H.F., Wold, E.D., Cotlier, E. and Reeser, F. Nutritional cataracts in timer wolves. J. Am. Veter. Med. Assn. 179:1175-1180, 1981.
4. Cotlier, E. and Sharma, Y.R. Senile cataract and plasma tryptophan. The Lancet, Sept. 5, f1981, p. 534.
5. Cicchetti, D.V., Sharma, Y.R., and Cotlier, E. Assessment of observer variability in the classification of human cataracts. Yale J. Biol. And Med. 55:81-88, 1982.
6. Cotlier, E., Sharma, Y.R., Niven, T. and Brescia, M. distribution of salicylate in lenses and intraocular fluids and effect on cataract formation. Am. J. Med. Supp. 83-90, June 14, 1983.
7. Cotlier, E., Fagadau, W., and Cicchetti, D.V. Methods for evaluation of medical therapy of senile and diabetic cataracts. Trans. Ophth. Soc. U.K. 102:416, 1982.
8. Jacobson, M., Sharma, Y.R., Cotlier, E., and Hollander, J.D. Diabetic complications in lens and nerve and their prevention by sulindac or sorbinil: Two novel aldose reductase inhibitors. Inv. Ophth. And Vis. Sciences, Vol. 24, 10:1426-1429, 1983.
9. Urban, R., and Cotlier, E. Corticosteroid-induced cataracts. Survey Ophth.: 31:102-110, 1986.
10. Cotlier, E. Cataract Image Analysis System. Eye 24:602, 2000.
AGE RELATED MACULAR DEGENERATION
RECENT PRESENTATIONS
1. ANNUAL GUEST LECTURE
“The Genetic Basis and Evaluation of Clinical Trials for Therapy of Age-Related Macular Degeneration.” Department of Ophthalmology, University of Puerto Rico, Pan American Course, San Juan, PR: February 1999/2000/2001/2002.
2. Discussion of paper by Small, K. et al “Genetic of Age-Related Macular Degeneration” at the 3rd Annual Meeting, Division of Ophthalmology, Cedars-Sinai Medical Center, Los Angeles, CA: January 2000.
3. “AGE RELATED MACULAR DEGENERATION: Evaluation of New Detection Procedures and New Therapies,” Ophthalmological Society of New York, New York, NY: July 2001. United Nations Medical Forum, New York, NY: September 2002.
CLINICAL TRIALS IN PROGRESS
As Principal Investigator (Gulden Ophthalmics)
Evaluation of the Gulden Photo stress system versus fluorescein angiography and contrast sensitivity in Age-Related Macular Degeneration.
Began April 2002. Recruited 82 patients. Total recruitment goal 250 patients.
As C0-investigator
Animal Model for Age Related Macular Degeneration and Cataracts and Primates.
NIH-University of Puerto Rico Primate Monkey Colony, San Juan PR.
CONSULTANT
At Veterans Administration Programs
NEI/NIH Cataract and Age Related Macular Degeneration- Clinical Evaluation and Vitamin Trials: 1985-1992.
At Surgex Technology (1995- 2001)
Evaluation of medical and surgical therapies for cataracts and age related macular degeneration. American Academy of Ophthalmology: 1998, 2000, 2001.
As Editor, Current Research Section, Survey of Ophthalmology
Review of articles submitted in the area of cataract and age related macular degeneration.
PHARMACEUTICAL INDUSTRY CONSULTANT/CLINICAL TRIALS RESEARCH
1. Boots international: Drugs effective of therapy of glaucoma.
2. Alcon Pharmaceuticals: Drug effects on diabetic retinopathy and cataracts.
3. Angelini Co.: Drug effect on development of cataracts.
4. Merck and Aspirin Foundation of America: Effects of aspirin on diabetic eye complications..
Books/Editor:
1. The Eye and Inborn Errors of Metabolism. The National Foundation- March of Dimes (with Bergsma, D., M.D. and Bron, A., F.R.C.S.), Alan R. Liss, Inc., publ., New York, NY, 1976.
2. Genetic Eye diseases. Retinitis Pigmentosa and Other Inherited Eye Diseases (with Maumenee, I.,M.D. and Bermand, E., Ph.D.). March of Dimes- Birth Defects Series, Alan R. Liss, Inc.,publ.,Vol.18:6, 1982.
3. Congenital Cataracts (with S. Lambert, M.D. and D. Taylor F.R.C.S.). Medical Intelligence Series, R.G. Landis Co. Austin, TX, 1994.
Book Chapters:
1. Emery and Rimoin’s Principles and Practice of Medical Genetics. Churchill Livingston Publishers, 3rd edition 1988; 4th edition 2002.
Editorial Boards/Journals:
Editor, Current Research Section, Survey of Ophthalmology, 1975-Present.
Editor-in-Chief, Ophthalmic Pediatrics and Genetics, 1984-1989.
Editorial Board, international Ophthalmology, 1977-1987.
AAO Continuing Education course (Physiology & Biochemistry, Section III).
Manuscript Reviewer: Experimental Eye Research, Inv. Ophthal. & Vis. Sciences.
American Journal of Ophthalmology, Science, Experientia, American Journal of human Genetics, Archives of Ophthalmology.
